Abstract template

Important phenomena were discovered that oxygen-containing expanded graphite an Oxidized OligoGraphene (OOG) obtained after hydrothermic treatment of modified graphite became to be able to interact as sorbent OOG with glycopeptide antibiotics. Introduction. In this work was studied the sorption properties of carbon material as an example of Oxidized OligoGraphene (OOG) concerning glycopeptide antibiotics clinically important groups, as well as study conditions desorption from OOG of antibiotics of this group. OOG version of ultrafine carbon sorbent, which was developed on the basis of the modified oxygen-containing expanded graphite (OCEG). OOG is a potential sorbent for the separation of the antibiotic from the culture medium producing strain after the fermentation process. Originally studied sorption characteristics of OOG with respect to antibiotics-standards as an example of clinically important glycopeptide (VancomycinRistomycin) group to which are known antibiotics vancomycin, ristomycin, teicoplanin A2, ehremomitcin. The interest to antibiotics of this group is steadily increasing, it is associated with a sufficiently high their stability with respect to MDR Gram-positive microorganisms such as: Methicillin Resistant Staphylococus Aureus (MRSA), Methicillin Resistant Staphylococcus epidermidis (MRSE), Clostridium difficile, enterococcs, pneumococcs, and others, so antibiotics -glikopeptids become indispensable in the treatment of infections caused by these microorganisms. Sorption of antibiotics–glykopeptides on OOG. Technological feature of OOG as sorbent is need of filling of its openwork structure with solution in which tests were carried out it. Follows from the obtained data that anti-biotics-glikopeptides possess ability to be oc-cluded on OOG in the chosen conditions. And the quantity of a sorbed antibiotic increases with increase in time of sorption. For an eremomitsin, a vankomitsin and a teykoplanin the liquid phase of a sorbent served in all experiments as "transit area" the antibiotic was immobilized on a carbon matrix and its share in a liquid phase of a sorbent didn't exceed 23% of all mass of the antibiotic accumulated on a sorbent. Thus, during the conducted research high sorption ability of a new sorbent of OOG concerning a number of antibiotics-glikopeptides for the first time is established [1]. Desorption of antibiotics from OOG. It is established that degree of a desorption of antibiotics from OOG depends on properties of organic solvent and also on structure of the analyzed antibiotic. It is shown that antibiotics, stripped from OOG, keep the physical and chemical properties and antibacterial activity. The obtained data by results of researches on sorption and a desorption allow to claim that OOG can be used in practice of allocation of antibiotics – polypeptides from solutions. Conclusions. Researches have the theoretical and practical importance, the received results can be applied both in screening new antibiotics, and at allocation and cleaning of already known antibiotics in production.